منابع مشابه
The E1 Proteins
The papillomavirus E1 protein is the ‘initiator’ protein for viral DNA replication and thus plays a critical role in maintenance of the viral genome as an episome during the viral life cycle. E1 shows some sequence and structural similarities to the simian virus 40 and polyomavirus large T antigen initiators (12), and its biochemical properties are consistent with its role as a replication init...
متن کاملThe E1 proteins.
E1, an ATP-dependent DNA helicase, is the only enzyme encoded by papillomaviruses (PVs). It is essential for replication and amplification of the viral episome in the nucleus of infected cells. To do so, E1 assembles into a double-hexamer at the viral origin, unwinds DNA at the origin and ahead of the replication fork and interacts with cellular DNA replication factors. Biochemical and structur...
متن کاملCharacterization of the murine cytomegalovirus early transcription unit e1 that is induced by immediate-early proteins.
The regulation of murine cytomegalovirus early (E) gene expression was studied in the cell line B25, which is stably transfected with the immediate-early ie1/ie3 gene complex. Infection of B25 cells in the presence of the protein synthesis inhibitor cycloheximide resulted in the expression of some E genes, whereas for the expression of other E genes prior protein synthesis was still mandatory, ...
متن کاملRemarks on E1-E2 and E1-M1 two-photon transitions
2014 We investigate the possibility to observe Doppler-free two-photon transitions in the case where one of the transitions is an electric dipole transition and the other one is a magnetic dipole or an electric quadrupole transition. We show that it is not possible to obtain Doppler-free lines by reflecting the beam on itself. On the other hand, such an effect should be observable if the two co...
متن کاملCross-inhibition of chikungunya virus fusion and infection by alphavirus E1 domain III proteins.
Alphaviruses are small enveloped RNA viruses that include important emerging human pathogens, such as chikungunya virus (CHIKV). These viruses infect cells via a low-pH-triggered membrane fusion reaction, making this step a potential target for antiviral therapies. The E1 fusion protein inserts into the target membrane, trimerizes, and refolds to a hairpin-like conformation in which the combina...
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ژورنال
عنوان ژورنال: Virology
سال: 2013
ISSN: 0042-6822
DOI: 10.1016/j.virol.2013.07.020